The invention presents an innovative, sustainable, and nano-sized platform for antigen delivery in aquaculture. This technology presents extracellular vesicles (EVs) derived from nonpathogenic cyanobacteria to deliver biologically active antigens towards fish immunization. GreenNanoVax can customize cyanobacterial EVs by packaging them with tailored antigens.
Capture fisheries can no longer meet the ever-growing market demands in quantity and quality, pushing the aquaculture sector to expand rapidly. However, disease outbreaks in fish farms have important effects on commercial losses and impair the expansion of the industry. The massive mis(use) of antibiotics to control fish infections has resulted in the development of resistant strains, which have rendered antibiotic treatments ineffective. Simultaneously, the presence of antibiotic residues in aquaculture products for human consumption also represents an important threat to public health.
- Self-suffcient cyanobacteria;
- Highly sustainable and easily scalable synthesis and purification processes;
- Synechocystis sp. PCC 680 EVs are biocompatible with fish;
- Wide range of applications with possible delivery of proteins or enzymes.
- Immunization of fish in aquaculture to prevent disease outbreaks;
- Replacement or reduction of antibiotics in fish farming, addressing antibiotic resistance;
- Delivery of biologically active molecules in aquatic species;
- Potential adaptation for other veterinary or biotechnological uses in aquatic environments.
