Abstract: 

Therapeutic Agent and Analytical Probe for Cell Biology Studies sed in the Inhibition of the P53-MDM2 Interaction.

Background: 

Therapeutic Agent and Analytical Probe for Cell Biology Studies sed in the Inhibition of the P53-MDM2 Interaction.

Benefits: 

Favourable apparent permeability coefficients was obtained and no cytotoxicity was observed. 
From commercial available building blocks only four steps are required for their synthesis; the synthesis was proven to be suitable for scale-up. 
Therefore, these derivatives can be used as probes in the p53-signalling pathway reseach field involving the p53 interaction with its endogenous negative regulator MDM2. Additionally, a formulation containing these compounds as effective components may be used in the treatment of cancer.

Potential comercial use/applications: 

Analytical probe for cell biology
Therapeutic compound